CRISPR-U™ Gene Knockout Cell Line Strategy

MVP Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human MVP Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol MVP
Gene id 9961
Organism Homo sapiens
Official full symbol major vault protein
Gene type protein-coding
Also known as LRP, VAULT1
Summary This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Genomic regions Chromosome 16
Strategy Summary
This gene has 9 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
MVP-202 ENST00000395353.5 2925 893aa Protein coding CCDS10656 Q14764 X5D2M8 - TSL:5, GENCODE basic, APPRIS P1,
MVP-201 ENST00000357402.10 2798 893aa Protein coding CCDS10656 Q14764 X5D2M8 NM_005115.5 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
MVP-207 ENST00000563915.5 854 220aa Protein coding - H3BQK6 - CDS 3' incomplete, TSL:3,
MVP-218 ENST00000570234.5 658 148aa Protein coding - H3BRL2 - CDS 3' incomplete, TSL:4,
MVP-206 ENST00000563558.5 548 144aa Protein coding - H3BNF6 - CDS 3' incomplete, TSL:4,
MVP-210 ENST00000566066.5 548 94aa Protein coding - H3BP76 - CDS 3' incomplete, TSL:4,
MVP-211 ENST00000566252.1 408 107aa Protein coding - H3BUK7 - CDS 3' incomplete, TSL:3,
MVP-208 ENST00000565164.1 211 42aa Protein coding - H3BNF2 - CDS 3' incomplete, TSL:5,
MVP-219 ENST00000629059.1 120 39aa Protein coding - H3BPZ2 - TSL:5, GENCODE basic,
MVP-213 ENST00000566859.5 589 81aa Nonsense mediated decay - H3BQE7 - TSL:5,
MVP-205 ENST00000563123.1 575 61aa Nonsense mediated decay - I3L155 - CDS 5' incomplete, TSL:4,
MVP-216 ENST00000569887.1 549 39aa Nonsense mediated decay - H3BPZ2 - TSL:5,
MVP-203 ENST00000562463.5 525 57aa Nonsense mediated decay - H3BUP3 - TSL:4,
MVP-212 ENST00000566554.1 811 No protein Processed transcript - - - TSL:4,
MVP-217 ENST00000570061.1 674 No protein Processed transcript - - - TSL:4,
MVP-209 ENST00000565830.5 557 No protein Processed transcript - - - TSL:4,
MVP-215 ENST00000569612.1 2091 No protein Retained intron - - - TSL:1,
MVP-214 ENST00000568068.1 561 No protein Retained intron - - - TSL:2,
MVP-204 ENST00000563096.1 546 No protein Retained intron - - - TSL:4,
Ubigene Red Cotton Transcript
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Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene MVP
This KO Strategy loading
Red Cotton™ Notes Gene MVP had been KO in hela cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
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