Official symbol | ISG15 |
Gene id | 9636 |
Organism | Homo sapiens |
Official full symbol | ISG15 ubiquitin like modifier |
Gene type | protein-coding |
Also known as | G1P2, IFI15, IMD38, IP17, UCRP, hUCRP |
Summary | The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. |
Genomic regions | Chromosome 1 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
ISG15-203 | ENST00000649529.1 | 637 | 165aa | Protein coding | CCDS6 | P05161 | NM_005101.4 | GENCODE basic, APPRIS P1, MANE Select v0.92, |
ISG15-202 | ENST00000624697.4 | 787 | 157aa | Protein coding | - | A0A096LPJ4 | - | TSL:3, GENCODE basic, |
ISG15-201 | ENST00000624652.1 | 657 | 143aa | Protein coding | - | A0A096LNZ9 | - | CDS 3' incomplete, TSL:3, |
Target Gene | ISG15 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene ISG15 had been KO in a549 cell line. |
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