CRISPR-U™ Gene Knockout Cell Line Strategy

OSMR Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human OSMR Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol OSMR
Gene id 9180
Organism Homo sapiens
Official full symbol oncostatin M receptor
Gene type protein-coding
Also known as IL-31R-beta, IL-31RB, OSMRB, OSMRbeta, PLCA1
Summary This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Genomic regions Chromosome 5
Strategy Summary
This gene has 3 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
OSMR-201 ENST00000274276.8 5526 979aa Protein coding CCDS3928 Q99650-1 NM_003999.3 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
OSMR-202 ENST00000502536.5 1740 342aa Protein coding CCDS54847 Q99650-2 - TSL:1, GENCODE basic,
OSMR-205 ENST00000513831.1 766 188aa Protein coding - H0Y9E3 - CDS 5' incomplete, TSL:3,
OSMR-204 ENST00000509237.5 653 62aa Nonsense mediated decay - H0YAD1 - CDS 5' incomplete, TSL:5,
OSMR-203 ENST00000508882.1 361 35aa Nonsense mediated decay - H0Y8W9 - CDS 5' incomplete, TSL:3,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene OSMR
This KO Strategy loading
Red Cotton™ Notes Gene OSMR had been KO in hela cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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