Official symbol | CCND3 |
Gene id | 896 |
Organism | Homo sapiens |
Official full symbol | cyclin D3 |
Gene type | protein-coding |
Summary | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. |
Genomic regions | Chromosome 6 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
CCND3-215 | ENST00000511642.5 | 2394 | 211aa | Protein coding | CCDS47426 | P30281-2 | - | TSL:2, GENCODE basic, |
CCND3-201 | ENST00000372987.8 | 2233 | 242aa | Protein coding | CCDS75452 | Q5T8J1 | - | TSL:2, GENCODE basic, |
CCND3-202 | ENST00000372988.8 | 2133 | 211aa | Protein coding | CCDS47426 | P30281-2 | - | TSL:1, GENCODE basic, |
CCND3-223 | ENST00000616010.4 | 2047 | 96aa | Protein coding | CCDS47427 | P30281-4 | - | TSL:5, GENCODE basic, |
CCND3-203 | ENST00000372991.9 | 2026 | 292aa | Protein coding | CCDS4863 | P30281-1 | NM_001760.5 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
CCND3-205 | ENST00000415497.6 | 1843 | 96aa | Protein coding | CCDS47427 | P30281-4 | - | TSL:2, GENCODE basic, |
CCND3-204 | ENST00000414200.6 | 1724 | 220aa | Protein coding | CCDS47425 | P30281-3 | - | TSL:2, GENCODE basic, |
CCND3-213 | ENST00000510503.5 | 1257 | 195aa | Protein coding | - | D6RI00 | - | TSL:3, GENCODE basic, |
CCND3-218 | ENST00000512426.5 | 876 | 175aa | Protein coding | - | H0Y8M4 | - | CDS 5' incomplete, TSL:2, |
CCND3-211 | ENST00000508143.5 | 574 | 10aa | Protein coding | - | A0A1D5RMS0 | - | CDS 3' incomplete, TSL:4, |
CCND3-206 | ENST00000502771.1 | 544 | 43aa | Protein coding | - | D6RDL3 | - | CDS 3' incomplete, TSL:4, |
CCND3-207 | ENST00000505064.1 | 540 | 118aa | Protein coding | - | D6RIX2 | - | CDS 3' incomplete, TSL:2, |
CCND3-221 | ENST00000514588.1 | 490 | 46aa | Protein coding | - | D6RDF8 | - | CDS 3' incomplete, TSL:4, |
CCND3-216 | ENST00000511686.5 | 576 | No protein | Processed transcript | - | - | - | TSL:3, |
CCND3-219 | ENST00000513956.5 | 562 | No protein | Processed transcript | - | - | - | TSL:2, |
CCND3-222 | ENST00000612455.1 | 536 | No protein | Processed transcript | - | - | - | TSL:NA, |
CCND3-220 | ENST00000514382.5 | 476 | No protein | Processed transcript | - | - | - | TSL:4, |
CCND3-217 | ENST00000512381.1 | 432 | No protein | Processed transcript | - | - | - | TSL:3, |
CCND3-210 | ENST00000506555.5 | 308 | No protein | Processed transcript | - | - | - | TSL:3, |
CCND3-208 | ENST00000505672.5 | 932 | No protein | Retained intron | - | - | - | TSL:2, |
CCND3-212 | ENST00000510058.1 | 926 | No protein | Retained intron | - | - | - | TSL:2, |
CCND3-209 | ENST00000505884.5 | 592 | No protein | Retained intron | - | - | - | TSL:4, |
CCND3-214 | ENST00000511161.5 | 579 | No protein | Retained intron | - | - | - | TSL:4, |
Target Gene | CCND3 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene CCND3 had been KO in hela cell line. |
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