Official symbol | BTRC |
Gene id | 8945 |
Organism | Homo sapiens |
Official full symbol | beta-transducin repeat containing E3 ubiquitin protein ligase |
Gene type | protein-coding |
Also known as | BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP |
Summary | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. |
Genomic regions | Chromosome 10 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
BTRC-203 | ENST00000393441.8 | 6084 | 579aa | Protein coding | CCDS73183 | B7Z3H4 | - | TSL:1, GENCODE basic, |
BTRC-202 | ENST00000370187.8 | 6024 | 605aa | Protein coding | CCDS7512 | Q9Y297-1 | NM_033637.4 | TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92, |
BTRC-204 | ENST00000408038.6 | 5982 | 569aa | Protein coding | CCDS7511 | Q9Y297-2 | - | TSL:1, GENCODE basic, APPRIS ALT1, |
BTRC-201 | ENST00000370183.2 | 655 | 191aa | Protein coding | - | Q5T1W7 | - | CDS 3' incomplete, TSL:3, |
BTRC-207 | ENST00000493877.1 | 772 | No protein | Processed transcript | - | - | - | TSL:5, |
BTRC-205 | ENST00000465182.1 | 685 | No protein | Processed transcript | - | - | - | TSL:3, |
BTRC-206 | ENST00000475200.5 | 527 | No protein | Processed transcript | - | - | - | TSL:3, |
Target Gene | BTRC |
This KO Strategy | loading |
Red Cotton™ Notes | Gene BTRC had been KO in hek293t cell line. |
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