Official symbol | CCND2 |
Gene id | 894 |
Organism | Homo sapiens |
Official full symbol | cyclin D2 |
Gene type | protein-coding |
Also known as | KIAK0002, MPPH3 |
Summary | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). |
Genomic regions | Chromosome 12 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
CCND2-208 | ENST00000676411.1 | 6849 | 289aa | Protein coding | CCDS8524 | - | - | APPRIS P1, |
CCND2-201 | ENST00000261254.8 | 6493 | 289aa | Protein coding | CCDS8524 | P30279-1 | NM_001759.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
CCND2-207 | ENST00000676279.1 | 6352 | 289aa | Protein coding | CCDS8524 | - | - | APPRIS P1, |
CCND2-206 | ENST00000675880.1 | 6532 | 303aa | Protein coding | - | - | - | GENCODE basic, |
CCND2-205 | ENST00000675468.1 | 6135 | No protein | Processed transcript | - | - | - | - |
CCND2-202 | ENST00000536537.2 | 1062 | No protein | Processed transcript | - | - | - | TSL:5, |
CCND2-203 | ENST00000536795.1 | 572 | No protein | Retained intron | - | - | - | TSL:3, |
CCND2-204 | ENST00000541542.1 | 322 | No protein | Retained intron | - | - | - | TSL:3, |
Target Gene | CCND2 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene CCND2 had been KO in hek293t cell line. |
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