Official symbol | CDC16 |
Gene id | 8881 |
Organism | Homo sapiens |
Official full symbol | cell division cycle 16 |
Gene type | protein-coding |
Also known as | ANAPC6, APC6, CDC16Hs, CUT9 |
Summary | The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. |
Genomic regions | Chromosome 13 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
CDC16-203 | ENST00000356221.8 | 2331 | 620aa | Protein coding | CCDS9542 | Q13042-1 | NM_001078645.3 | TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92, |
CDC16-204 | ENST00000360383.7 | 2211 | 620aa | Protein coding | CCDS9542 | Q13042-1 | - | TSL:5, GENCODE basic, APPRIS P4, |
CDC16-206 | ENST00000375310.5 | 2156 | 526aa | Protein coding | CCDS81787 | Q13042-4 | - | TSL:1, GENCODE basic, |
CDC16-201 | ENST00000252457.9 | 2034 | 619aa | Protein coding | CCDS81786 | Q13042-2 | - | TSL:1, GENCODE basic, APPRIS ALT1, |
CDC16-205 | ENST00000375308.5 | 2034 | 526aa | Protein coding | CCDS81787 | Q13042-4 | - | TSL:1, GENCODE basic, |
CDC16-211 | ENST00000628084.2 | 2058 | 475aa | Protein coding | - | Q5T8C6 | - | TSL:5, GENCODE basic, |
CDC16-202 | ENST00000252458.6 | 1991 | 475aa | Protein coding | - | Q5T8C6 | - | TSL:1, GENCODE basic, |
CDC16-212 | ENST00000650489.1 | 2204 | 539aa | Nonsense mediated decay | - | A0A3B3ISD2 | - | - |
CDC16-207 | ENST00000461716.1 | 700 | No protein | Processed transcript | - | - | - | TSL:5, |
CDC16-209 | ENST00000494581.1 | 614 | No protein | Processed transcript | - | - | - | TSL:3, |
CDC16-208 | ENST00000484907.1 | 1038 | No protein | Retained intron | - | - | - | TSL:3, |
CDC16-210 | ENST00000494766.5 | 1003 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | CDC16 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene CDC16 had been KO in hek293t cell line. |
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