CRISPR-U™ Gene Knockout Cell Line Strategy

TRIM24 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human TRIM24 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol TRIM24
Gene id 8805
Organism Homo sapiens
Official full symbol tripartite motif containing 24
Gene type protein-coding
Also known as PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1
Summary The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Genomic regions Chromosome 7
Strategy Summary
This gene has 2 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
TRIM24-201 ENST00000343526.9 8488 1050aa Protein coding CCDS5847 O15164-1 NM_015905.3 TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92,
TRIM24-202 ENST00000415680.6 3799 1016aa Protein coding CCDS47720 O15164-2 - TSL:1, GENCODE basic, APPRIS ALT2,
TRIM24-206 ENST00000497516.5 1515 No protein Processed transcript - - - TSL:5,
TRIM24-205 ENST00000493595.1 811 No protein Processed transcript - - - TSL:3,
TRIM24-203 ENST00000464210.1 545 No protein Processed transcript - - - TSL:4,
TRIM24-204 ENST00000485318.1 539 No protein Processed transcript - - - TSL:4,
Ubigene Red Cotton Transcript
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Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene TRIM24
This KO Strategy loading
Red Cotton™ Notes Gene TRIM24 had been KO in hela cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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