Official symbol | TNFRSF10B |
Gene id | 8795 |
Organism | Homo sapiens |
Official full symbol | TNF receptor superfamily member 10b |
Gene type | protein-coding |
Also known as | CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 |
Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. |
Genomic regions | Chromosome 8 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
TNFRSF10B-201 | ENST00000276431.9 | 3998 | 440aa | Protein coding | CCDS6035 | O14763-1 | NM_003842.5 | TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92, |
TNFRSF10B-202 | ENST00000347739.3 | 1723 | 411aa | Protein coding | CCDS6036 | O14763-2 | - | TSL:1, GENCODE basic, APPRIS ALT2, |
TNFRSF10B-207 | ENST00000523504.5 | 1464 | 90aa | Nonsense mediated decay | - | E9PBT3 | - | TSL:2, |
TNFRSF10B-205 | ENST00000519910.1 | 546 | No protein | Processed transcript | - | - | - | TSL:4, |
TNFRSF10B-208 | ENST00000523752.5 | 3328 | No protein | Retained intron | - | - | - | TSL:1, |
TNFRSF10B-206 | ENST00000520109.1 | 674 | No protein | Retained intron | - | - | - | TSL:2, |
TNFRSF10B-204 | ENST00000519028.1 | 612 | No protein | Retained intron | - | - | - | TSL:2, |
TNFRSF10B-203 | ENST00000518531.5 | 564 | No protein | Retained intron | - | - | - | TSL:3, |
Target Gene | TNFRSF10B |
This KO Strategy | loading |
Red Cotton™ Notes | Gene TNFRSF10B had been KO in hela cell line. |
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