Official symbol | CDC14B |
Gene id | 8555 |
Organism | Homo sapiens |
Official full symbol | cell division cycle 14B |
Gene type | protein-coding |
Also known as | CDC14B3, Cdc14B1, Cdc14B2, hCDC14B |
Summary | The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. |
Genomic regions | Chromosome 9 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
CDC14B-202 | ENST00000375241.6 | 5602 | 498aa | Protein coding | CCDS6722 | O60729-1 | NM_033331.4 | TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92, |
CDC14B-203 | ENST00000375242.7 | 2965 | 461aa | Protein coding | CCDS43853 | O60729-5 | - | TSL:2, GENCODE basic, APPRIS ALT1, |
CDC14B-201 | ENST00000375240.7 | 2547 | 459aa | Protein coding | CCDS6721 | O60729-2 | - | TSL:1, GENCODE basic, APPRIS ALT2, |
CDC14B-208 | ENST00000463569.5 | 1734 | 485aa | Protein coding | CCDS87662 | O60729-4 | - | TSL:5, GENCODE basic, APPRIS ALT2, |
CDC14B-206 | ENST00000452280.5 | 804 | 268aa | Protein coding | - | H0Y577 | - | CDS 5' and 3' incomplete, TSL:3, |
CDC14B-205 | ENST00000415608.1 | 684 | 228aa | Protein coding | - | Q5JU07 | - | CDS 5' and 3' incomplete, TSL:5, |
CDC14B-204 | ENST00000412285.6 | 5271 | 480aa | Nonsense mediated decay | - | H7C3U8 | - | CDS 5' incomplete, TSL:1, |
CDC14B-209 | ENST00000474602.5 | 4960 | 471aa | Nonsense mediated decay | - | O60729-3 | - | TSL:1, |
CDC14B-211 | ENST00000481149.1 | 689 | No protein | Processed transcript | - | - | - | TSL:3, |
CDC14B-207 | ENST00000463547.5 | 553 | No protein | Processed transcript | - | - | - | TSL:4, |
CDC14B-210 | ENST00000480920.5 | 459 | No protein | Processed transcript | - | - | - | TSL:3, |
CDC14B-213 | ENST00000496750.5 | 649 | No protein | Retained intron | - | - | - | TSL:3, |
CDC14B-212 | ENST00000484948.1 | 350 | No protein | Retained intron | - | - | - | TSL:5, |
Target Gene | CDC14B |
This KO Strategy | loading |
Red Cotton™ Notes | Gene CDC14B had been KO in hek293t cell line. |
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