Official symbol | MAPKAPK5 |
Gene id | 8550 |
Organism | Homo sapiens |
Official full symbol | MAPK activated protein kinase 5 |
Gene type | protein-coding |
Also known as | MAPKAP-K5, MK-5, MK5, PRAK |
Summary | The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Genomic regions | Chromosome 12 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
MAPKAPK5-206 | ENST00000550735.7 | 11083 | 471aa | Protein coding | CCDS44976 | Q8IW41-2 | NM_003668.4 | TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92, |
MAPKAPK5-207 | ENST00000551404.6 | 1630 | 473aa | Protein coding | CCDS44975 | Q8IW41-1 | - | TSL:5, GENCODE basic, APPRIS ALT1, |
MAPKAPK5-205 | ENST00000549875.1 | 974 | 324aa | Protein coding | - | R4GN33 | - | CDS 3' incomplete, TSL:5, |
MAPKAPK5-203 | ENST00000547305.1 | 494 | 51aa | Protein coding | - | R4GN93 | - | TSL:2, GENCODE basic, |
MAPKAPK5-209 | ENST00000553053.5 | 875 | 74aa | Nonsense mediated decay | - | F8VRP2 | - | TSL:5, |
MAPKAPK5-201 | ENST00000546394.1 | 567 | No protein | Processed transcript | - | - | - | TSL:3, |
MAPKAPK5-202 | ENST00000547067.1 | 1459 | No protein | Retained intron | - | - | - | TSL:2, |
MAPKAPK5-204 | ENST00000547915.1 | 1360 | No protein | Retained intron | - | - | - | TSL:3, |
MAPKAPK5-208 | ENST00000552111.5 | 954 | No protein | Retained intron | - | - | - | TSL:3, |
MAPKAPK5-210 | ENST00000602983.1 | 392 | No protein | Retained intron | - | - | - | TSL:NA, |
Target Gene | MAPKAPK5 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene MAPKAPK5 had been KO in hek293t cell line. |
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