Official symbol | PPP1R16A |
Gene id | 84988 |
Organism | Homo sapiens |
Official full symbol | protein phosphatase 1 regulatory subunit 16A |
Gene type | protein-coding |
Also known as | MYPT3 |
Summary | Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. |
Genomic regions | Chromosome 8 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
PPP1R16A-201 | ENST00000292539.8 | 2722 | 528aa | Protein coding | CCDS6429 | Q96I34 | - | TSL:2, GENCODE basic, APPRIS P1, |
PPP1R16A-202 | ENST00000435887.1 | 2273 | 528aa | Protein coding | CCDS6429 | Q96I34 | - | TSL:1, GENCODE basic, APPRIS P1, |
PPP1R16A-207 | ENST00000529009.1 | 657 | 65aa | Protein coding | - | A0A087WWZ0 | - | CDS 3' incomplete, TSL:3, |
PPP1R16A-208 | ENST00000529283.5 | 636 | No protein | Processed transcript | - | - | - | TSL:5, |
PPP1R16A-210 | ENST00000533088.1 | 577 | No protein | Processed transcript | - | - | - | TSL:2, |
PPP1R16A-211 | ENST00000533829.1 | 558 | No protein | Processed transcript | - | - | - | TSL:3, |
PPP1R16A-203 | ENST00000526183.5 | 4311 | No protein | Retained intron | - | - | - | TSL:2, |
PPP1R16A-206 | ENST00000528430.2 | 807 | No protein | Retained intron | - | - | - | TSL:2, |
PPP1R16A-209 | ENST00000532806.1 | 747 | No protein | Retained intron | - | - | - | TSL:5, |
PPP1R16A-204 | ENST00000526564.1 | 675 | No protein | Retained intron | - | - | - | TSL:5, |
PPP1R16A-205 | ENST00000526643.1 | 663 | No protein | Retained intron | - | - | - | TSL:4, |
Target Gene | PPP1R16A |
This KO Strategy | loading |
Red Cotton™ Notes | Gene PPP1R16A had been KO in hek293t cell line. |
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