Official symbol | ATG4C |
Gene id | 84938 |
Organism | Homo sapiens |
Official full symbol | autophagy related 4C cysteine peptidase |
Gene type | protein-coding |
Also known as | APG4-C, APG4C, AUTL1, AUTL3 |
Summary | Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. |
Genomic regions | Chromosome 1 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
ATG4C-201 | ENST00000317868.9 | 2944 | 458aa | Protein coding | CCDS623 | A0A384MTY5 Q96DT6 | NM_032852.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
ATG4C-203 | ENST00000371120.7 | 2890 | 458aa | Protein coding | CCDS623 | A0A384MTY5 Q96DT6 | - | TSL:1, GENCODE basic, APPRIS P1, |
ATG4C-202 | ENST00000371118.1 | 665 | 189aa | Protein coding | - | A6NGQ4 | - | CDS 3' incomplete, TSL:5, |
ATG4C-205 | ENST00000443289.5 | 603 | 151aa | Protein coding | - | C9JC51 | - | CDS 3' incomplete, TSL:2, |
ATG4C-204 | ENST00000414558.2 | 464 | 110aa | Protein coding | - | H7BZW5 | - | CDS 5' incomplete, TSL:5, |
Target Gene | ATG4C |
This KO Strategy | loading |
Red Cotton™ Notes | Gene ATG4C had been KO in hek293t cell line. |
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