Official symbol | HAVCR2 |
Gene id | 84868 |
Organism | Homo sapiens |
Official full symbol | hepatitis A virus cellular receptor 2 |
Gene type | protein-coding |
Also known as | CD366, HAVcr-2, KIM-3, SPTCL, TIM3, TIMD-3, TIMD3, Tim-3 |
Summary | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. |
Genomic regions | Chromosome 5 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
HAVCR2-201 | ENST00000307851.9 | 2237 | 301aa | Protein coding | CCDS4333 | Q8TDQ0-1 | NM_032782.5 | TSL:1, GENCODE basic, APPRIS P2, MANE Select v0.92, |
HAVCR2-204 | ENST00000522593.5 | 975 | 273aa | Protein coding | - | E5RHN3 | - | TSL:5, GENCODE basic, APPRIS ALT2, |
HAVCR2-206 | ENST00000524219.1 | 566 | 74aa | Protein coding | - | E5RFR4 | - | CDS 3' incomplete, TSL:4, |
HAVCR2-202 | ENST00000517358.1 | 566 | No protein | Processed transcript | - | - | - | TSL:4, |
HAVCR2-205 | ENST00000522902.1 | 1010 | No protein | Retained intron | - | - | - | TSL:1, |
HAVCR2-203 | ENST00000521665.1 | 795 | No protein | Retained intron | - | - | - | TSL:1, |
Target Gene | HAVCR2 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene HAVCR2 had been KO in hela cell line. |
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