Official symbol | ANTXR1 |
Gene id | 84168 |
Organism | Homo sapiens |
Official full symbol | ANTXR cell adhesion molecule 1 |
Gene type | protein-coding |
Also known as | ATR, GAPO, TEM8 |
Summary | This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. |
Genomic regions | Chromosome 2 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
ANTXR1-201 | ENST00000303714.9 | 5858 | 564aa | Protein coding | CCDS1892 | Q9H6X2-1 | NM_032208.3 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
ANTXR1-203 | ENST00000409829.7 | 2221 | 333aa | Protein coding | CCDS46314 | Q9H6X2-4 | - | TSL:1, GENCODE basic, |
ANTXR1-202 | ENST00000409349.7 | 1384 | 368aa | Protein coding | CCDS46313 | Q9H6X2-2 | - | TSL:1, GENCODE basic, |
ANTXR1-211 | ENST00000681816.1 | 1989 | 346aa | Protein coding | - | - | - | GENCODE basic, |
ANTXR1-204 | ENST00000463335.2 | 1449 | 297aa | Protein coding | - | - | - | TSL:1, GENCODE basic, |
ANTXR1-208 | ENST00000679548.1 | 1261 | 351aa | Protein coding | - | - | - | CDS 5' incomplete, |
ANTXR1-206 | ENST00000482235.2 | 1126 | 347aa | Protein coding | - | H0YC24 | - | TSL:3, GENCODE basic, |
ANTXR1-209 | ENST00000681059.1 | 3862 | No protein | Processed transcript | - | - | - | - |
ANTXR1-210 | ENST00000681568.1 | 4853 | No protein | Retained intron | - | - | - | - |
ANTXR1-205 | ENST00000481119.2 | 2955 | No protein | Retained intron | - | - | - | TSL:3, |
ANTXR1-207 | ENST00000497197.3 | 480 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | ANTXR1 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene ANTXR1 had been KO in hela cell line. |
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