Official symbol | TIAL1 |
Gene id | 7073 |
Organism | Homo sapiens |
Official full symbol | TIA1 cytotoxic granule associated RNA binding protein like 1 |
Gene type | protein-coding |
Also known as | TCBP, TIAR |
Summary | The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. |
Genomic regions | Chromosome 10 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
TIAL1-203 | ENST00000369093.6 | 5072 | 392aa | Protein coding | CCDS31295 | Q01085-2 | - | TSL:2, GENCODE basic, |
TIAL1-205 | ENST00000436547.7 | 3827 | 375aa | Protein coding | CCDS7613 | Q01085-1 | NM_003252.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
TIAL1-204 | ENST00000412524.5 | 515 | 132aa | Protein coding | - | E7ETJ9 | - | CDS 3' incomplete, TSL:5, |
TIAL1-201 | ENST00000369086.1 | 490 | 85aa | Protein coding | - | A6NKZ9 | - | TSL:2, |
TIAL1-213 | ENST00000497671.5 | 2321 | 135aa | Nonsense mediated decay | - | E7ETC0 | - | TSL:1, |
TIAL1-210 | ENST00000479729.1 | 485 | 28aa | Nonsense mediated decay | - | A0A087WX93 | - | TSL:3, |
TIAL1-207 | ENST00000463089.6 | 907 | No protein | Processed transcript | - | - | - | TSL:5, |
TIAL1-208 | ENST00000470635.1 | 336 | No protein | Processed transcript | - | - | - | TSL:3, |
TIAL1-206 | ENST00000462373.1 | 260 | No protein | Processed transcript | - | - | - | TSL:3, |
TIAL1-211 | ENST00000489822.5 | 2222 | No protein | Retained intron | - | - | - | TSL:2, |
TIAL1-209 | ENST00000470781.5 | 1727 | No protein | Retained intron | - | - | - | TSL:2, |
TIAL1-202 | ENST00000369087.5 | 1566 | No protein | Retained intron | - | - | - | TSL:2, |
TIAL1-212 | ENST00000495821.1 | 372 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | TIAL1 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene TIAL1 had been KO in hela cell line. |
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