Official symbol | STAT5B |
Gene id | 6777 |
Organism | Homo sapiens |
Official full symbol | signal transducer and activator of transcription 5B |
Gene type | protein-coding |
Also known as | STAT5 |
Summary | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. |
Genomic regions | Chromosome 17 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
STAT5B-201 | ENST00000293328.8 | 5079 | 787aa | Protein coding | CCDS11423 | P51692 | NM_012448.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
STAT5B-202 | ENST00000415845.1 | 559 | 156aa | Protein coding | - | C9J4I3 | - | CDS 3' incomplete, TSL:4, |
STAT5B-203 | ENST00000468312.1 | 1799 | No protein | Retained intron | - | - | - | TSL:1, |
STAT5B-206 | ENST00000481517.1 | 999 | No protein | Retained intron | - | - | - | TSL:4, |
STAT5B-204 | ENST00000468496.5 | 897 | No protein | Retained intron | - | - | - | TSL:5, |
STAT5B-207 | ENST00000498674.1 | 542 | No protein | Retained intron | - | - | - | TSL:4, |
STAT5B-205 | ENST00000481253.2 | 491 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | STAT5B |
This KO Strategy | loading |
Red Cotton™ Notes | Gene STAT5B had been KO in hela cell line. |
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