Official symbol | SOD2 |
Gene id | 6648 |
Organism | Homo sapiens |
Official full symbol | superoxide dismutase 2 |
Gene type | protein-coding |
Also known as | GClnc1, IPO-B, IPOB, MNSOD, MVCD6, Mn-SOD |
Summary | This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. |
Genomic regions | Chromosome 6 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
SOD2-210 | ENST00000538183.7 | 14167 | 222aa | Protein coding | CCDS5265 | P04179-1 | NM_000636.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
SOD2-214 | ENST00000546087.5 | 2558 | 176aa | Protein coding | CCDS83141 | - | - | TSL:2, GENCODE basic, |
SOD2-206 | ENST00000452684.2 | 2045 | 140aa | Protein coding | CCDS83142 | G5E9P6 | - | TSL:1, GENCODE basic, |
SOD2-201 | ENST00000337404.8 | 991 | 183aa | Protein coding | CCDS34564 | P04179-2 | - | TSL:2, GENCODE basic, |
SOD2-203 | ENST00000367055.8 | 990 | 222aa | Protein coding | CCDS5265 | P04179-1 | - | TSL:1, GENCODE basic, APPRIS P1, |
SOD2-205 | ENST00000444946.6 | 917 | 162aa | Protein coding | CCDS83143 | P04179-3 | - | TSL:2, GENCODE basic, |
SOD2-202 | ENST00000367054.6 | 815 | 183aa | Protein coding | CCDS34564 | P04179-2 | - | TSL:2, GENCODE basic, |
SOD2-213 | ENST00000545162.5 | 571 | 190aa | Protein coding | - | F5GYZ5 | - | CDS 3' incomplete, TSL:3, |
SOD2-208 | ENST00000535561.5 | 551 | 183aa | Protein coding | - | F5H4R2 | - | CDS 3' incomplete, TSL:3, |
SOD2-204 | ENST00000401980.3 | 523 | 61aa | Protein coding | - | G8JLJ2 | - | CDS 3' incomplete, TSL:4, |
SOD2-209 | ENST00000537657.5 | 507 | 111aa | Protein coding | - | F5H3C5 | - | CDS 3' incomplete, TSL:2, |
SOD2-215 | ENST00000546260.5 | 4302 | 141aa | Nonsense mediated decay | - | F5GXZ9 | - | TSL:5, |
SOD2-212 | ENST00000541573.5 | 573 | No protein | Processed transcript | - | - | - | TSL:4, |
SOD2-211 | ENST00000540491.1 | 454 | No protein | Processed transcript | - | - | - | TSL:3, |
SOD2-207 | ENST00000535459.5 | 581 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | SOD2 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene SOD2 had been KO in hek293t cell line. |
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