CRISPR-U™ Gene Knockout Cell Line Strategy

BMPR1A Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human BMPR1A Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol BMPR1A
Gene id 657
Organism Homo sapiens
Official full symbol bone morphogenetic protein receptor type 1A
Gene type protein-coding
Also known as 10q23del, ACVRLK3, ALK3, CD292, SKR5
Summary The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
Genomic regions Chromosome 10
Strategy Summary
This gene has 2 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
BMPR1A-201 ENST00000372037.8 6417 532aa Protein coding CCDS7378 P36894 NM_004329.3 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
BMPR1A-202 ENST00000480152.2 421 41aa Protein coding - A0A087X0P8 - CDS 3' incomplete, TSL:3,
BMPR1A-205 ENST00000638429.1 5632 532aa Nonsense mediated decay CCDS7378 P36894 - TSL:5,
BMPR1A-203 ENST00000635816.1 3238 532aa Nonsense mediated decay CCDS7378 P36894 - TSL:5,
BMPR1A-204 ENST00000636056.1 3233 532aa Nonsense mediated decay CCDS7378 P36894 - TSL:5,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene BMPR1A
This KO Strategy loading
Red Cotton™ Notes Gene BMPR1A had been KO in hela cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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