Official symbol | BLMH |
Gene id | 642 |
Organism | Homo sapiens |
Official full symbol | bleomycin hydrolase |
Gene type | protein-coding |
Also known as | BH, BMH |
Summary | Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. |
Genomic regions | Chromosome 17 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
BLMH-201 | ENST00000261714.11 | 2307 | 455aa | Protein coding | CCDS32604 | Q13867 | NM_000386.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
BLMH-213 | ENST00000584603.2 | 1020 | 318aa | Protein coding | - | K7ES02 | - | CDS 3' incomplete, TSL:5, |
BLMH-204 | ENST00000577623.5 | 823 | 231aa | Protein coding | - | K7ESE8 | - | CDS 3' incomplete, TSL:5, |
BLMH-210 | ENST00000581037.5 | 788 | 262aa | Protein coding | - | J3KSD8 | - | CDS 5' and 3' incomplete, TSL:5, |
BLMH-209 | ENST00000580709.1 | 561 | 67aa | Protein coding | - | K7EMJ3 | - | CDS 3' incomplete, TSL:4, |
BLMH-205 | ENST00000578090.5 | 1483 | 71aa | Nonsense mediated decay | - | J3KS79 | - | TSL:2, |
BLMH-202 | ENST00000577290.1 | 586 | 93aa | Nonsense mediated decay | - | K7ENH5 | - | TSL:4, |
BLMH-211 | ENST00000582669.1 | 477 | No protein | Processed transcript | - | - | - | TSL:4, |
BLMH-206 | ENST00000578795.1 | 2079 | No protein | Retained intron | - | - | - | TSL:NA, |
BLMH-212 | ENST00000582749.1 | 769 | No protein | Retained intron | - | - | - | TSL:2, |
BLMH-203 | ENST00000577306.1 | 761 | No protein | Retained intron | - | - | - | TSL:2, |
BLMH-207 | ENST00000579325.1 | 585 | No protein | Retained intron | - | - | - | TSL:3, |
BLMH-208 | ENST00000579957.1 | 293 | No protein | Retained intron | - | - | - | TSL:1, |
Target Gene | BLMH |
This KO Strategy | loading |
Red Cotton™ Notes | Gene BLMH had been KO in hela cell line. |
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