Official symbol | IFIH1 |
Gene id | 64135 |
Organism | Homo sapiens |
Official full symbol | interferon induced with helicase C domain 1 |
Gene type | protein-coding |
Also known as | AGS7, Hlcd, IDDM19, MDA-5, MDA5, RLR-2, SGMRT1 |
Summary | IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome |
Genomic regions | Chromosome 2 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
IFIH1-206 | ENST00000649979.2 | 3581 | 1025aa | Protein coding | CCDS2217 | Q9BYX4-1 | NM_022168.4 | GENCODE basic, APPRIS P1, MANE Select v0.92, |
IFIH1-203 | ENST00000648433.1 | 3234 | 986aa | Protein coding | - | A0A3B3IRK8 | - | GENCODE basic, |
IFIH1-207 | ENST00000679938.1 | 2964 | 921aa | Protein coding | - | - | - | GENCODE basic, |
IFIH1-201 | ENST00000421365.2 | 1617 | 221aa | Protein coding | - | Q9BYX4-2 | - | TSL:1, GENCODE basic, |
IFIH1-205 | ENST00000649554.1 | 2795 | No protein | Processed transcript | - | - | - | - |
IFIH1-204 | ENST00000649426.1 | 791 | No protein | Retained intron | - | - | - | - |
IFIH1-202 | ENST00000464129.1 | 567 | No protein | Retained intron | - | - | - | TSL:4, |
Target Gene | IFIH1 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene IFIH1 had been KO in a549 cell line. |
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