Official symbol | PTBP1 |
Gene id | 5725 |
Organism | Homo sapiens |
Official full symbol | polypyrimidine tract binding protein 1 |
Gene type | protein-coding |
Also known as | HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB |
Summary | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. |
Genomic regions | Chromosome 19 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
PTBP1-203 | ENST00000356948.11 | 3206 | 557aa | Protein coding | CCDS42456 | P26599-3 | NM_002819.5 | TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92, |
PTBP1-204 | ENST00000394601.8 | 3185 | 550aa | Protein coding | CCDS45892 | P26599-2 | - | TSL:1, GENCODE basic, |
PTBP1-201 | ENST00000349038.8 | 3155 | 531aa | Protein coding | CCDS32859 | P26599-1 | - | TSL:1, GENCODE basic, APPRIS ALT1, |
PTBP1-220 | ENST00000635647.1 | 3691 | 588aa | Protein coding | - | A0A0U1RRM4 | - | TSL:5, GENCODE basic, |
PTBP1-224 | ENST00000679114.1 | 3233 | 559aa | Protein coding | - | - | - | GENCODE basic, |
PTBP1-202 | ENST00000350092.8 | 3069 | 527aa | Protein coding | - | A6NLN1 | - | TSL:1, GENCODE basic, |
PTBP1-219 | ENST00000627714.2 | 2201 | 197aa | Protein coding | - | A0A0D9SF20 | - | TSL:5, GENCODE basic, |
PTBP1-208 | ENST00000585956.5 | 767 | 256aa | Protein coding | - | K7EK45 | - | CDS 5' and 3' incomplete, TSL:3, |
PTBP1-213 | ENST00000589575.5 | 749 | 237aa | Protein coding | - | K7EKJ7 | - | CDS 3' incomplete, TSL:3, |
PTBP1-209 | ENST00000586481.5 | 578 | 149aa | Protein coding | - | K7ES59 | - | CDS 3' incomplete, TSL:3, |
PTBP1-212 | ENST00000587191.3 | 357 | 81aa | Protein coding | - | A0A087WUW5 | - | CDS 3' incomplete, TSL:5, |
PTBP1-205 | ENST00000585535.2 | 314 | 105aa | Protein coding | - | K7ELW5 | - | CDS 5' and 3' incomplete, TSL:3, |
PTBP1-221 | ENST00000676227.1 | 3275 | 339aa | Nonsense mediated decay | - | - | - | - |
PTBP1-222 | ENST00000677277.1 | 3194 | 313aa | Nonsense mediated decay | - | - | - | - |
PTBP1-218 | ENST00000621737.4 | 1125 | 227aa | Nonsense mediated decay | - | A0A087WU68 | - | CDS 5' incomplete, TSL:5, |
PTBP1-207 | ENST00000585932.5 | 1030 | 115aa | Nonsense mediated decay | - | A0A087WTS6 | - | CDS 5' incomplete, TSL:3, |
PTBP1-210 | ENST00000586944.5 | 4661 | No protein | Retained intron | - | - | - | TSL:2, |
PTBP1-217 | ENST00000592804.2 | 1556 | No protein | Retained intron | - | - | - | TSL:2, |
PTBP1-216 | ENST00000592113.5 | 1548 | No protein | Retained intron | - | - | - | TSL:5, |
PTBP1-206 | ENST00000585856.2 | 1217 | No protein | Retained intron | - | - | - | TSL:2, |
PTBP1-223 | ENST00000677717.1 | 723 | No protein | Retained intron | - | - | - | - |
PTBP1-214 | ENST00000589883.1 | 683 | No protein | Retained intron | - | - | - | TSL:3, |
PTBP1-215 | ENST00000590887.5 | 642 | No protein | Retained intron | - | - | - | TSL:3, |
PTBP1-211 | ENST00000587136.1 | 583 | No protein | Retained intron | - | - | - | TSL:3, |
Target Gene | PTBP1 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene PTBP1 had been KO in hela cell line. |
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