Official symbol | PSMD8 |
Gene id | 5714 |
Organism | Homo sapiens |
Official full symbol | proteasome 26S subunit, non-ATPase 8 |
Gene type | protein-coding |
Also known as | HEL-S-91n, HIP6, HYPF, Nin1p, Rpn12, S14, p31 |
Summary | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. |
Genomic regions | Chromosome 19 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
PSMD8-210 | ENST00000620216.4 | 1538 | 350aa | Protein coding | CCDS12515 | P48556 V9HW09 | - | TSL:1, GENCODE basic, APPRIS P1, |
PSMD8-201 | ENST00000215071.9 | 1518 | 350aa | Protein coding | CCDS12515 | P48556 V9HW09 | NM_002812.5 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
PSMD8-207 | ENST00000592035.5 | 1581 | 172aa | Protein coding | - | K7EJC1 | - | TSL:1, GENCODE basic, |
PSMD8-209 | ENST00000602911.5 | 1330 | 287aa | Protein coding | - | R4GMR5 | - | TSL:1, GENCODE basic, |
PSMD8-208 | ENST00000592561.5 | 771 | 250aa | Protein coding | - | K7EJR3 | - | CDS 3' incomplete, TSL:2, |
PSMD8-205 | ENST00000591250.1 | 578 | 67aa | Protein coding | - | K7ERW6 | - | CDS 3' incomplete, TSL:3, |
PSMD8-202 | ENST00000585598.1 | 541 | 129aa | Protein coding | - | K7ENY6 | - | TSL:5, GENCODE basic, |
PSMD8-203 | ENST00000590331.1 | 422 | 63aa | Nonsense mediated decay | - | K7EK21 | - | CDS 5' incomplete, TSL:2, |
PSMD8-206 | ENST00000592001.5 | 853 | No protein | Retained intron | - | - | - | TSL:2, |
PSMD8-204 | ENST00000591216.1 | 611 | No protein | Retained intron | - | - | - | TSL:3, |
Target Gene | PSMD8 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene PSMD8 had been KO in hek293t cell line. |
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