Official symbol | NSUN2 |
Gene id | 54888 |
Organism | Homo sapiens |
Official full symbol | NOP2/Sun RNA methyltransferase 2 |
Gene type | protein-coding |
Also known as | MISU, MRT5, SAKI, TRM4 |
Summary | This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
Genomic regions | Chromosome 5 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
NSUN2-201 | ENST00000264670.11 | 3056 | 767aa | Protein coding | CCDS3869 | Q08J23-1 | NM_017755.6 | TSL:1, GENCODE basic, APPRIS P2, MANE Select v0.92, |
NSUN2-206 | ENST00000506139.5 | 2619 | 732aa | Protein coding | CCDS54832 | Q08J23-2 | - | TSL:2, GENCODE basic, APPRIS ALT2, |
NSUN2-203 | ENST00000504374.5 | 3217 | 202aa | Nonsense mediated decay | - | A0A140T9Y7 | - | TSL:2, |
NSUN2-209 | ENST00000514127.1 | 614 | 102aa | Nonsense mediated decay | - | A0A140T9Z1 | - | CDS 5' incomplete, TSL:3, |
NSUN2-204 | ENST00000505264.1 | 472 | No protein | Processed transcript | - | - | - | TSL:4, |
NSUN2-205 | ENST00000505892.5 | 3558 | No protein | Retained intron | - | - | - | TSL:1, |
NSUN2-208 | ENST00000513888.5 | 1290 | No protein | Retained intron | - | - | - | TSL:2, |
NSUN2-207 | ENST00000507888.1 | 715 | No protein | Retained intron | - | - | - | TSL:3, |
NSUN2-202 | ENST00000502932.1 | 512 | No protein | Retained intron | - | - | - | TSL:3, |
Target Gene | NSUN2 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene NSUN2 had been KO in hek293t cell line. |
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