Official symbol | PGR |
Gene id | 5241 |
Organism | Homo sapiens |
Official full symbol | progesterone receptor |
Gene type | protein-coding |
Also known as | NR3C3, PR |
Summary | This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. |
Genomic regions | Chromosome 11 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
PGR-202 | ENST00000325455.10 | 13037 | 933aa | Protein coding | CCDS8310 | P06401-1 | NM_000926.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
PGR-207 | ENST00000534013.5 | 1901 | 339aa | Protein coding | CCDS59229 | P06401-3 | - | TSL:2, GENCODE basic, |
PGR-210 | ENST00000619228.2 | 3038 | 764aa | Protein coding | - | Q8NG44 | - | TSL:5, GENCODE basic, |
PGR-209 | ENST00000617858.4 | 2816 | 690aa | Protein coding | - | A0A087WXR4 | - | TSL:5, GENCODE basic, |
PGR-201 | ENST00000263463.9 | 2496 | 831aa | Protein coding | - | P06401-5 | - | TSL:1, GENCODE basic, |
PGR-211 | ENST00000632634.1 | 551 | 170aa | Protein coding | - | A0A0J9YVP1 | - | CDS 3' incomplete, TSL:3, |
PGR-208 | ENST00000534780.5 | 2750 | 803aa | Nonsense mediated decay | - | Q8NG42 | - | TSL:1, |
PGR-204 | ENST00000528960.5 | 2633 | 764aa | Nonsense mediated decay | - | Q8NG44 | - | TSL:1, |
PGR-203 | ENST00000526300.5 | 2365 | 695aa | Nonsense mediated decay | - | Q8NG45 | - | TSL:1, |
PGR-206 | ENST00000533207.5 | 2224 | No protein | Retained intron | - | - | - | TSL:1, |
PGR-205 | ENST00000530764.1 | 620 | No protein | Retained intron | - | - | - | TSL:3, |
Target Gene | PGR |
This KO Strategy | loading |
Red Cotton™ Notes | Gene PGR had been KO in hela cell line. |
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