Official symbol | PDK4 |
Gene id | 5166 |
Organism | Homo sapiens |
Official full symbol | pyruvate dehydrogenase kinase 4 |
Gene type | protein-coding |
Summary | This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. |
Genomic regions | Chromosome 7 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
PDK4-201 | ENST00000005178.6 | 3601 | 411aa | Protein coding | CCDS5643 | A4D1H4 Q16654 | NM_002612.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
PDK4-204 | ENST00000473796.1 | 2136 | No protein | Retained intron | - | - | - | TSL:2, |
PDK4-203 | ENST00000473301.1 | 691 | No protein | Retained intron | - | - | - | TSL:2, |
PDK4-202 | ENST00000468445.1 | 572 | No protein | Retained intron | - | - | - | TSL:4, |
PDK4-205 | ENST00000498190.1 | 420 | No protein | Retained intron | - | - | - | TSL:3, |
Target Gene | PDK4 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene PDK4 had been KO in hela cell line. |
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