CRISPR-U™ Gene Knockout Cell Line Strategy

COA4 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human COA4 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol COA4
Gene id 51287
Organism Homo sapiens
Official full symbol cytochrome c oxidase assembly factor 4 homolog
Gene type protein-coding
Also known as CHCHD8, CMC3, E2IG2
Genomic regions Chromosome 11
Strategy Summary
This gene has 4 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
COA4-206 ENST00000545127.1 922 87aa Protein coding CCDS8225 Q9NYJ1-1 - TSL:2, GENCODE basic, APPRIS P1,
COA4-201 ENST00000355693.5 818 87aa Protein coding CCDS8225 Q9NYJ1-1 NM_016565.3 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
COA4-202 ENST00000537289.1 582 87aa Protein coding CCDS8225 Q9NYJ1-1 - TSL:2, GENCODE basic, APPRIS P1,
COA4-204 ENST00000541455.1 1038 96aa Protein coding - Q9NYJ1-2 - TSL:5, GENCODE basic,
COA4-203 ENST00000537581.1 566 No protein Processed transcript - - - TSL:4,
COA4-205 ENST00000544575.1 449 No protein Processed transcript - - - TSL:3,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene COA4
This KO Strategy loading
Red Cotton™ Notes Gene COA4 had been KO in hek293t cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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