CRISPR-U™ Gene Knockout Cell Line Strategy

CRIM1 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human CRIM1 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol CRIM1
Gene id 51232
Organism Homo sapiens
Official full symbol cysteine rich transmembrane BMP regulator 1
Gene type protein-coding
Also known as CRIM-1, S52
Summary This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins.
Genomic regions Chromosome 2
Strategy Summary
This gene has 4 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
CRIM1-201 ENST00000280527.7 6060 1036aa Protein coding CCDS1783 Q9NZV1 NM_016441.3 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
CRIM1-202 ENST00000413985.1 874 175aa Protein coding - H7C1Z0 - CDS 5' incomplete, TSL:3,
CRIM1-204 ENST00000428774.1 700 55aa Protein coding - H7C458 - CDS 5' incomplete, TSL:3,
CRIM1-203 ENST00000426856.1 667 222aa Protein coding - H7C2T6 - CDS 5' and 3' incomplete, TSL:3,
CRIM1-205 ENST00000473403.5 386 No protein Processed transcript - - - TSL:3,
CRIM1-206 ENST00000477491.5 311 No protein Processed transcript - - - TSL:2,
CRIM1-208 ENST00000497236.1 240 No protein Processed transcript - - - TSL:3,
CRIM1-207 ENST00000481321.1 346 No protein Retained intron - - - TSL:3,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene CRIM1
This KO Strategy loading
Red Cotton™ Notes Gene CRIM1 had been KO in hek293t cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

Please leave your suggestion ×