Official symbol | PCNT |
Gene id | 5116 |
Organism | Homo sapiens |
Official full symbol | pericentrin |
Gene type | protein-coding |
Also known as | KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4 |
Summary | The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. |
Genomic regions | Chromosome 21 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
PCNT-201 | ENST00000359568.10 | 10526 | 3336aa | Protein coding | CCDS33592 | O95613-1 | NM_006031.6 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
PCNT-202 | ENST00000418394.1 | 796 | 228aa | Protein coding | - | H7C2A3 | - | CDS 5' incomplete, TSL:3, |
PCNT-205 | ENST00000480896.5 | 10485 | No protein | Processed transcript | - | - | - | TSL:1, |
PCNT-208 | ENST00000490468.5 | 1415 | No protein | Processed transcript | - | - | - | TSL:5, |
PCNT-204 | ENST00000466474.5 | 895 | No protein | Processed transcript | - | - | - | TSL:3, |
PCNT-207 | ENST00000483844.1 | 734 | No protein | Processed transcript | - | - | - | TSL:3, |
PCNT-206 | ENST00000482575.1 | 578 | No protein | Processed transcript | - | - | - | TSL:3, |
PCNT-203 | ENST00000465356.1 | 767 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | PCNT |
This KO Strategy | loading |
Red Cotton™ Notes | Gene PCNT had been KO in hela cell line. |
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