Official symbol | PAK2 |
Gene id | 5062 |
Organism | Homo sapiens |
Official full symbol | p21 (RAC1) activated kinase 2 |
Gene type | protein-coding |
Also known as | PAK65, PAKgamma |
Summary | The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. |
Genomic regions | Chromosome 3 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
PAK2-201 | ENST00000327134.7 | 6139 | 524aa | Protein coding | CCDS3321 | Q13177 | NM_002577.4 | TSL:2, GENCODE basic, APPRIS P1, MANE Select v0.92, |
PAK2-202 | ENST00000426668.1 | 689 | 221aa | Protein coding | - | H7C1X3 | - | CDS 5' incomplete, TSL:3, |
PAK2-203 | ENST00000481344.1 | 371 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | PAK2 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene PAK2 had been KO in hela cell line. |
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