Official symbol | NTRK2 |
Gene id | 4915 |
Organism | Homo sapiens |
Official full symbol | neurotrophic receptor tyrosine kinase 2 |
Gene type | protein-coding |
Also known as | EIEE58, GP145-TrkB, OBHD, TRKB, trk-B |
Summary | This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. |
Genomic regions | Chromosome 9 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
NTRK2-206 | ENST00000376213.6 | 8693 | 822aa | Protein coding | CCDS35050 | Q16620-1 | - | TSL:5, GENCODE basic, APPRIS P4, |
NTRK2-201 | ENST00000277120.8 | 8666 | 838aa | Protein coding | CCDS6671 | Q16620-4 | NM_006180.6 | TSL:1, GENCODE basic, APPRIS ALT1, MANE Select v0.92, |
NTRK2-205 | ENST00000376208.6 | 8633 | 537aa | Protein coding | CCDS35052 | Q16620-3 | - | TSL:1, GENCODE basic, |
NTRK2-203 | ENST00000323115.10 | 8618 | 822aa | Protein coding | CCDS35050 | Q16620-1 | - | TSL:1, GENCODE basic, APPRIS P4, |
NTRK2-202 | ENST00000304053.10 | 8226 | 553aa | Protein coding | CCDS35051 | Q16620-5 | - | TSL:1, GENCODE basic, |
NTRK2-207 | ENST00000395882.6 | 7499 | 477aa | Protein coding | CCDS35053 | Q16620-2 | - | TSL:1, GENCODE basic, |
NTRK2-204 | ENST00000359847.4 | 7286 | 477aa | Protein coding | CCDS35053 | Q16620-2 | - | TSL:1, GENCODE basic, |
Target Gene | NTRK2 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene NTRK2 had been KO in hela cell line. |
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