CRISPR-U™ Gene Knockout Cell Line Strategy

NTRK2 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human NTRK2 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol NTRK2
Gene id 4915
Organism Homo sapiens
Official full symbol neurotrophic receptor tyrosine kinase 2
Gene type protein-coding
Also known as EIEE58, GP145-TrkB, OBHD, TRKB, trk-B
Summary This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Genomic regions Chromosome 9
Strategy Summary
This gene has 7 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
NTRK2-206 ENST00000376213.6 8693 822aa Protein coding CCDS35050 Q16620-1 - TSL:5, GENCODE basic, APPRIS P4,
NTRK2-201 ENST00000277120.8 8666 838aa Protein coding CCDS6671 Q16620-4 NM_006180.6 TSL:1, GENCODE basic, APPRIS ALT1, MANE Select v0.92,
NTRK2-205 ENST00000376208.6 8633 537aa Protein coding CCDS35052 Q16620-3 - TSL:1, GENCODE basic,
NTRK2-203 ENST00000323115.10 8618 822aa Protein coding CCDS35050 Q16620-1 - TSL:1, GENCODE basic, APPRIS P4,
NTRK2-202 ENST00000304053.10 8226 553aa Protein coding CCDS35051 Q16620-5 - TSL:1, GENCODE basic,
NTRK2-207 ENST00000395882.6 7499 477aa Protein coding CCDS35053 Q16620-2 - TSL:1, GENCODE basic,
NTRK2-204 ENST00000359847.4 7286 477aa Protein coding CCDS35053 Q16620-2 - TSL:1, GENCODE basic,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene NTRK2
This KO Strategy loading
Red Cotton™ Notes Gene NTRK2 had been KO in hela cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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