Official symbol | NPR1 |
Gene id | 4881 |
Organism | Homo sapiens |
Official full symbol | natriuretic peptide receptor 1 |
Gene type | protein-coding |
Also known as | ANPRA, ANPa, GUC2A, GUCY2A, NPRA |
Summary | Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 ). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively). |
Genomic regions | Chromosome 1 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
NPR1-202 | ENST00000368680.4 | 4185 | 1061aa | Protein coding | CCDS1051 | A0A140VJE6 P16066 | NM_000906.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
NPR1-203 | ENST00000413826.1 | 473 | No protein | Processed transcript | - | - | - | TSL:3, |
NPR1-201 | ENST00000368677.2 | 1706 | No protein | Retained intron | - | - | - | TSL:5, |
Target Gene | NPR1 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene NPR1 had been KO in hela cell line. |
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