Official symbol | NEFM |
Gene id | 4741 |
Organism | Homo sapiens |
Official full symbol | neurofilament medium |
Gene type | protein-coding |
Also known as | NEF3, NF-M, NFM |
Summary | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Genomic regions | Chromosome 8 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
NEFM-201 | ENST00000221166.10 | 3271 | 916aa | Protein coding | CCDS6046 | P07197-1 | NM_005382.2 | TSL:1, GENCODE basic, APPRIS P2, MANE Select v0.92, |
NEFM-202 | ENST00000433454.3 | 2519 | 540aa | Protein coding | CCDS47831 | P07197-2 | - | TSL:2, GENCODE basic, |
NEFM-203 | ENST00000437366.2 | 3148 | 877aa | Protein coding | - | E7ESP9 | - | TSL:2, GENCODE basic, APPRIS ALT2, |
NEFM-204 | ENST00000518131.5 | 2500 | 698aa | Protein coding | - | E7EMV2 | - | TSL:2, GENCODE basic, APPRIS ALT2, |
NEFM-205 | ENST00000521540.1 | 1885 | No protein | Processed transcript | - | - | - | TSL:5, |
NEFM-206 | ENST00000523467.1 | 582 | No protein | Processed transcript | - | - | - | TSL:5, |
Target Gene | NEFM |
This KO Strategy | loading |
Red Cotton™ Notes | Gene NEFM had been KO in hek293t cell line. |
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