Official symbol | MATK |
Gene id | 4145 |
Organism | Homo sapiens |
Official full symbol | megakaryocyte-associated tyrosine kinase |
Gene type | protein-coding |
Also known as | CHK, CTK, HHYLTK, HYL, HYLTK, Lsk |
Summary | The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. |
Genomic regions | Chromosome 19 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
MATK-201 | ENST00000310132.11 | 2098 | 507aa | Protein coding | CCDS12114 | P42679-1 | NM_139355.3 | TSL:1, GENCODE basic, MANE Select v0.92, |
MATK-203 | ENST00000395045.6 | 2073 | 508aa | Protein coding | CCDS12113 | P42679-2 | - | TSL:2, GENCODE basic, |
MATK-202 | ENST00000395040.6 | 1907 | 466aa | Protein coding | CCDS42468 | P42679-3 | - | TSL:1, GENCODE basic, APPRIS P1, |
MATK-215 | ENST00000619596.4 | 1740 | 508aa | Protein coding | CCDS12113 | P42679-2 | - | TSL:2, GENCODE basic, |
MATK-204 | ENST00000585778.5 | 1994 | 506aa | Protein coding | - | K7EQY5 | - | TSL:1, GENCODE basic, |
MATK-208 | ENST00000590493.5 | 801 | 267aa | Protein coding | - | K7ES68 | - | CDS 5' and 3' incomplete, TSL:3, |
MATK-205 | ENST00000587180.1 | 741 | 131aa | Protein coding | - | K7ERY4 | - | CDS 3' incomplete, TSL:5, |
MATK-207 | ENST00000590028.5 | 724 | 174aa | Protein coding | - | K7ENL8 | - | CDS 3' incomplete, TSL:4, |
MATK-206 | ENST00000588983.5 | 711 | 237aa | Protein coding | - | K7EKS5 | - | CDS 5' and 3' incomplete, TSL:3, |
MATK-212 | ENST00000591059.1 | 594 | 13aa | Protein coding | - | K7EKC4 | - | CDS 3' incomplete, TSL:4, |
MATK-210 | ENST00000590849.1 | 571 | 84aa | Protein coding | - | K7EQV3 | - | CDS 3' incomplete, TSL:4, |
MATK-211 | ENST00000590980.1 | 562 | 38aa | Protein coding | - | K7EPP2 | - | CDS 3' incomplete, TSL:4, |
MATK-209 | ENST00000590821.1 | 659 | No protein | Processed transcript | - | - | - | TSL:3, |
MATK-214 | ENST00000592612.1 | 575 | No protein | Processed transcript | - | - | - | TSL:4, |
MATK-213 | ENST00000592300.1 | 544 | No protein | Processed transcript | - | - | - | TSL:4, |
Target Gene | MATK |
This KO Strategy | loading |
Red Cotton™ Notes | Gene MATK had been KO in hek293t cell line. |
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