Official symbol | LMO2 |
Gene id | 4005 |
Organism | Homo sapiens |
Official full symbol | LIM domain only 2 |
Gene type | protein-coding |
Also known as | LMO-2, RBTN2, RBTNL1, RHOM2, TTG2 |
Summary | LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Genomic regions | Chromosome 11 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
LMO2-201 | ENST00000257818.3 | 2081 | 227aa | Protein coding | CCDS7888 | P25791-3 | NM_005574.4 | TSL:1, GENCODE basic, MANE Select v0.92, |
LMO2-202 | ENST00000395833.7 | 1687 | 158aa | Protein coding | CCDS44567 | P25791-1 | - | TSL:1, GENCODE basic, APPRIS P1, |
LMO2-203 | ENST00000411482.1 | 1519 | 55aa | Nonsense mediated decay | - | P25791-4 | - | TSL:1, |
LMO2-206 | ENST00000493667.1 | 390 | No protein | Processed transcript | - | - | - | TSL:3, |
LMO2-204 | ENST00000464025.5 | 1550 | No protein | Retained intron | - | - | - | TSL:1, |
LMO2-205 | ENST00000465614.1 | 869 | No protein | Retained intron | - | - | - | TSL:5, |
Target Gene | LMO2 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene LMO2 had been KO in a549 cell line. |
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