CRISPR-U™ Gene Knockout Cell Line
Strategy
CXCL10 Gene Knockout Strategy
CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general
CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has
successfully edited over 3000 genes on more than 100 types of cell lines.
Objective
To create a Human CXCL10 Knockout
model in cell line by
CRISPR-U™-mediated
genome
engineering.
Target gene info 
| Official symbol | CXCL10 |
| Gene id | 3627 |
| Organism | Homo sapiens |
| Official full symbol | C-X-C motif chemokine ligand 10 |
| Gene type | protein-coding |
| Also known as | C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 |
| Summary | This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. |
| Genomic regions | Chromosome 4 |
Strategy Summary
This gene has 1 protein coding transcripts：
| Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
| CXCL10-201 | ENST00000306602.3 | 1175 | 98aa | Protein coding | CCDS43240 | P02778 | NM_001565.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
Red Cotton™ Assessment
Project Difficulty Level unknown
| Target Gene | CXCL10 |
| This KO Strategy | loading |
| Red Cotton™ Notes | Gene CXCL10 had been KO in a549 cell line. |
Aforementioned information comes from Ubigene database. Different origin of cell lines may have
different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:
$49
Single gRNA plasmid off-shelf
$599
Single gRNA lentivirus
Work flow
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