Official symbol | FAS |
Gene id | 355 |
Organism | Homo sapiens |
Official full symbol | Fas cell surface death receptor |
Gene type | protein-coding |
Also known as | ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 |
Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
Genomic regions | Chromosome 10 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
FAS-221 | ENST00000652046.1 | 3696 | 335aa | Protein coding | CCDS7393 | P25445-1 | NM_000043.6 | GENCODE basic, APPRIS P4, MANE Select v0.92, |
FAS-205 | ENST00000357339.6 | 1044 | 314aa | Protein coding | CCDS7394 | P25445-6 | - | TSL:1, GENCODE basic, APPRIS ALT2, |
FAS-203 | ENST00000355279.2 | 983 | 220aa | Protein coding | CCDS7395 | P25445-7 | - | TSL:1, GENCODE basic, |
FAS-204 | ENST00000355740.7 | 2605 | 197aa | Protein coding | - | K9J972 | - | TSL:1, GENCODE basic, |
FAS-202 | ENST00000352159.8 | 1722 | 233aa | Protein coding | - | H7C5Z8 | - | TSL:5, GENCODE basic, |
FAS-217 | ENST00000612663.5 | 1464 | 244aa | Nonsense mediated decay | - | A0A087WTM9 | - | TSL:5, |
FAS-211 | ENST00000484444.5 | 1076 | 103aa | Nonsense mediated decay | - | P25445-2 | - | TSL:1, |
FAS-215 | ENST00000494410.5 | 975 | 149aa | Nonsense mediated decay | - | P25445-4 | - | TSL:1, |
FAS-213 | ENST00000488877.5 | 924 | 149aa | Nonsense mediated decay | - | P25445-4 | - | TSL:1, |
FAS-210 | ENST00000479522.5 | 857 | 86aa | Nonsense mediated decay | - | P25445-3 | - | TSL:1, |
FAS-214 | ENST00000492756.5 | 836 | 132aa | Nonsense mediated decay | - | P25445-5 | - | TSL:1, |
FAS-218 | ENST00000640140.1 | 2262 | No protein | Processed transcript | - | - | - | TSL:5, |
FAS-220 | ENST00000640681.1 | 2221 | No protein | Processed transcript | - | - | - | TSL:5, |
FAS-219 | ENST00000640250.1 | 1598 | No protein | Processed transcript | - | - | - | TSL:5, |
FAS-201 | ENST00000313771.9 | 1044 | No protein | Processed transcript | - | - | - | TSL:1, |
FAS-212 | ENST00000487314.1 | 824 | No protein | Processed transcript | - | - | - | TSL:5, |
FAS-207 | ENST00000460510.5 | 810 | No protein | Processed transcript | - | - | - | TSL:3, |
FAS-209 | ENST00000477270.5 | 731 | No protein | Processed transcript | - | - | - | TSL:5, |
FAS-216 | ENST00000494799.5 | 681 | No protein | Processed transcript | - | - | - | TSL:3, |
FAS-208 | ENST00000466081.5 | 625 | No protein | Processed transcript | - | - | - | TSL:3, |
FAS-206 | ENST00000371857.7 | 1023 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | FAS |
This KO Strategy | loading |
Red Cotton™ Notes | Gene FAS had been KO in hela cell line. |
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