Official symbol | HSPB1 |
Gene id | 3315 |
Organism | Homo sapiens |
Official full symbol | heat shock protein family B (small) member 1 |
Gene type | protein-coding |
Also known as | CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 |
Summary | This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. |
Genomic regions | Chromosome 7 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
HSPB1-201 | ENST00000248553.7 | 777 | 205aa | Protein coding | CCDS5583 | P04792 V9HW43 | NM_001540.5 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
HSPB1-213 | ENST00000675538.1 | 812 | 174aa | Protein coding | - | - | - | GENCODE basic, |
HSPB1-218 | ENST00000676231.1 | 807 | 215aa | Protein coding | - | - | - | GENCODE basic, |
HSPB1-204 | ENST00000674547.1 | 800 | 143aa | Protein coding | - | - | - | GENCODE basic, |
HSPB1-216 | ENST00000675906.1 | 794 | 143aa | Protein coding | - | - | - | GENCODE basic, |
HSPB1-210 | ENST00000675226.1 | 776 | 162aa | Protein coding | - | - | - | GENCODE basic, |
HSPB1-206 | ENST00000674638.1 | 772 | 157aa | Protein coding | - | - | - | GENCODE basic, |
HSPB1-209 | ENST00000675134.1 | 756 | 198aa | Protein coding | - | - | - | GENCODE basic, |
HSPB1-207 | ENST00000674650.1 | 687 | 141aa | Protein coding | - | - | - | GENCODE basic, |
HSPB1-202 | ENST00000429938.1 | 527 | 37aa | Protein coding | - | C9J3N8 | - | TSL:1, GENCODE basic, |
HSPB1-208 | ENST00000674965.1 | 802 | 122aa | Nonsense mediated decay | - | - | - | - |
HSPB1-205 | ENST00000674560.1 | 436 | No protein | Processed transcript | - | - | - | - |
HSPB1-212 | ENST00000675488.1 | 435 | No protein | Processed transcript | - | - | - | - |
HSPB1-215 | ENST00000675733.1 | 435 | No protein | Processed transcript | - | - | - | - |
HSPB1-214 | ENST00000675624.1 | 434 | No protein | Processed transcript | - | - | - | - |
HSPB1-219 | ENST00000676398.1 | 434 | No protein | Processed transcript | - | - | - | - |
HSPB1-217 | ENST00000676195.1 | 144 | No protein | Processed transcript | - | - | - | - |
HSPB1-203 | ENST00000447574.1 | 1455 | No protein | Retained intron | - | - | - | TSL:1, |
HSPB1-211 | ENST00000675417.1 | 1089 | No protein | Retained intron | - | - | - | - |
Target Gene | HSPB1 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene HSPB1 had been KO in hela cell line. |
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