CRISPR-U™ Gene Knockout Cell Line Strategy

HNRNPAB Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human HNRNPAB Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol HNRNPAB
Gene id 3182
Organism Homo sapiens
Official full symbol heterogeneous nuclear ribonucleoprotein A/B
Gene type protein-coding
Also known as ABBP1, HNRPAB
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Genomic regions Chromosome 5
Strategy Summary
This gene has 7 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
HNRNPAB-204 ENST00000504898.5 1785 332aa Protein coding CCDS34309 Q99729-2 - TSL:1, GENCODE basic, APPRIS ALT2,
HNRNPAB-202 ENST00000358344.8 1770 332aa Protein coding CCDS34309 Q99729-2 NM_031266.3 TSL:1, GENCODE basic, APPRIS ALT2, MANE Select v0.92,
HNRNPAB-205 ENST00000506259.5 1674 285aa Protein coding CCDS34310 Q99729-3 - TSL:1, GENCODE basic, APPRIS P3,
HNRNPAB-201 ENST00000355836.9 1602 285aa Protein coding CCDS34310 Q99729-3 - TSL:1, GENCODE basic, APPRIS P3,
HNRNPAB-206 ENST00000506339.5 1747 327aa Protein coding - D6RBZ0 - TSL:5, GENCODE basic, APPRIS ALT2,
HNRNPAB-208 ENST00000515193.5 1595 280aa Protein coding - D6R9P3 - TSL:5, GENCODE basic, APPRIS ALT2,
HNRNPAB-207 ENST00000514633.5 1571 283aa Protein coding - D6RD18 - TSL:5, GENCODE basic, APPRIS ALT2,
HNRNPAB-203 ENST00000504796.1 578 No protein Retained intron - - - TSL:2,
Ubigene Red Cotton Transcript
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Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene HNRNPAB
This KO Strategy loading
Red Cotton™ Notes Gene HNRNPAB had been KO in hek293t cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
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