CRISPR-U™ Gene Knockout Cell Line Strategy

GMPR Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human GMPR Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol GMPR
Gene id 2766
Organism Homo sapiens
Official full symbol guanosine monophosphate reductase
Gene type protein-coding
Also known as GMPR 1, GMPR1
Summary This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.
Genomic regions Chromosome 6
Strategy Summary
This gene has 1 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
GMPR-201 ENST00000259727.5 1508 345aa Protein coding CCDS4537 P36959 NM_006877.4 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
GMPR-204 ENST00000544145.1 750 No protein Processed transcript - - - TSL:3,
GMPR-203 ENST00000543191.5 675 No protein Processed transcript - - - TSL:2,
GMPR-202 ENST00000540478.1 793 No protein Retained intron - - - TSL:2,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene GMPR
This KO Strategy loading
Red Cotton™ Notes Gene GMPR had been KO in a549 cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

Please leave your suggestion ×