Official symbol | MTHFD1L |
Gene id | 25902 |
Organism | Homo sapiens |
Official full symbol | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like |
Gene type | protein-coding |
Also known as | FTHFSDC1, MTC1THFS, dJ292B18.2 |
Summary | The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene. |
Genomic regions | Chromosome 6 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
MTHFD1L-211 | ENST00000611279.4 | 3475 | 979aa | Protein coding | CCDS75535 | B7ZM99 | - | TSL:5, GENCODE basic, APPRIS ALT2, |
MTHFD1L-203 | ENST00000367321.8 | 3451 | 978aa | Protein coding | CCDS5228 | Q6UB35-1 | NM_015440.5 | TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92, |
MTHFD1L-212 | ENST00000618312.4 | 3159 | 913aa | Protein coding | CCDS75536 | A0A087WVM4 | - | TSL:5, GENCODE basic, APPRIS ALT2, |
MTHFD1L-201 | ENST00000367307.8 | 1049 | 275aa | Protein coding | CCDS56457 | Q6UB35-2 | - | TSL:1, GENCODE basic, |
MTHFD1L-202 | ENST00000367308.8 | 996 | 332aa | Protein coding | - | H0Y327 | - | CDS 5' and 3' incomplete, TSL:5, |
MTHFD1L-204 | ENST00000420192.1 | 606 | 96aa | Protein coding | - | Q4VXV2 | - | CDS 5' incomplete, TSL:2, |
MTHFD1L-206 | ENST00000423867.2 | 524 | 114aa | Protein coding | - | Q5JYA3 | - | CDS 3' incomplete, TSL:2, |
MTHFD1L-209 | ENST00000453602.1 | 503 | 92aa | Protein coding | - | Q4VXM0 | - | CDS 5' incomplete, TSL:5, |
MTHFD1L-208 | ENST00000450635.1 | 427 | 57aa | Protein coding | - | Q4VXM1 | - | CDS 5' incomplete, TSL:5, |
MTHFD1L-207 | ENST00000441122.5 | 1134 | 108aa | Nonsense mediated decay | - | Q5JYA8 | - | TSL:5, |
MTHFD1L-210 | ENST00000478643.1 | 421 | No protein | Processed transcript | - | - | - | TSL:3, |
MTHFD1L-205 | ENST00000421497.1 | 373 | No protein | Processed transcript | - | - | - | TSL:3, |
Target Gene | MTHFD1L |
This KO Strategy | loading |
Red Cotton™ Notes | Gene MTHFD1L had been KO in hek293t cell line. |
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