CRISPR-U™ Gene Knockout Cell Line Strategy

CORO1C Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human CORO1C Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol CORO1C
Gene id 23603
Organism Homo sapiens
Official full symbol coronin 1C
Gene type protein-coding
Also known as HCRNN4
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene.
Genomic regions Chromosome 12
Strategy Summary
This gene has 12 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
CORO1C-202 ENST00000420959.6 3921 527aa Protein coding CCDS61236 Q9ULV4-3 - TSL:1, GENCODE basic,
CORO1C-201 ENST00000261401.8 3814 474aa Protein coding CCDS9120 Q9ULV4-1 NM_014325.4 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
CORO1C-204 ENST00000541050.5 2487 474aa Protein coding CCDS9120 Q9ULV4-1 - TSL:2, GENCODE basic, APPRIS P1,
CORO1C-212 ENST00000549772.5 1710 480aa Protein coding - Q9ULV4-2 - TSL:1, GENCODE basic,
CORO1C-203 ENST00000421578.6 1296 369aa Protein coding - B4E3S0 - TSL:2, GENCODE basic,
CORO1C-205 ENST00000546571.5 899 162aa Protein coding - F8VSA4 - CDS 3' incomplete, TSL:4,
CORO1C-219 ENST00000552871.5 587 125aa Protein coding - F8VV53 - CDS 3' incomplete, TSL:3,
CORO1C-206 ENST00000546705.5 577 165aa Protein coding - H0YHL7 - CDS 5' incomplete, TSL:3,
CORO1C-215 ENST00000551044.1 567 151aa Protein coding - F8W1H8 - CDS 3' incomplete, TSL:3,
CORO1C-208 ENST00000547294.5 566 181aa Protein coding - F8VVB7 - CDS 3' incomplete, TSL:5,
CORO1C-213 ENST00000550032.5 547 169aa Protein coding - F8VTT6 - CDS 3' incomplete, TSL:2,
CORO1C-217 ENST00000551550.5 547 163aa Protein coding - F8VRE9 - CDS 3' incomplete, TSL:4,
CORO1C-214 ENST00000550542.5 1245 159aa Nonsense mediated decay - F8VUX3 - TSL:5,
CORO1C-210 ENST00000549384.5 891 No protein Processed transcript - - - TSL:5,
CORO1C-218 ENST00000552030.5 547 No protein Processed transcript - - - TSL:5,
CORO1C-211 ENST00000549387.1 873 No protein Retained intron - - - TSL:3,
CORO1C-207 ENST00000547170.1 804 No protein Retained intron - - - TSL:4,
CORO1C-209 ENST00000547361.1 683 No protein Retained intron - - - TSL:2,
CORO1C-216 ENST00000551059.1 474 No protein Retained intron - - - TSL:2,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene CORO1C
This KO Strategy loading
Red Cotton™ Notes Gene CORO1C had been KO in hek293t cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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