Official symbol | FLT3 |
Gene id | 2322 |
Organism | Homo sapiens |
Official full symbol | fms related receptor tyrosine kinase 3 |
Gene type | protein-coding |
Also known as | CD135, FLK-2, FLK2, STK1 |
Summary | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
Genomic regions | Chromosome 13 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
FLT3-201 | ENST00000241453.12 | 3826 | 993aa | Protein coding | CCDS31953 | P36888-1 | NM_004119.3 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
FLT3-202 | ENST00000380987.2 | 3634 | 739aa | Nonsense mediated decay | - | E7ER61 | - | TSL:1, |
FLT3-203 | ENST00000469894.1 | 474 | No protein | Processed transcript | - | - | - | TSL:3, |
Target Gene | FLT3 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene FLT3 had been KO in hela cell line. |
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