CRISPR-U™ Gene Knockout Cell Line Strategy

JMJD6 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human JMJD6 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol JMJD6
Gene id 23210
Organism Homo sapiens
Official full symbol jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Gene type protein-coding
Also known as PSR, PTDSR, PTDSR1
Summary This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Genomic regions Chromosome 17
Strategy Summary
This gene has 4 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
JMJD6-203 ENST00000445478.6 5303 414aa Protein coding CCDS42383 Q6NYC1-3 - TSL:1, GENCODE basic, APPRIS ALT1,
JMJD6-202 ENST00000397625.9 1621 403aa Protein coding CCDS42384 Q6NYC1-1 NM_015167.3 TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92,
JMJD6-208 ENST00000617192.4 5517 361aa Protein coding - B2WTI4 - TSL:5, GENCODE basic,
JMJD6-205 ENST00000585429.1 1330 395aa Protein coding - K7EJU9 - TSL:5, GENCODE basic,
JMJD6-204 ENST00000542934.5 1898 361aa Nonsense mediated decay - B2WTI4 - TSL:2,
JMJD6-201 ENST00000303996.10 1893 335aa Nonsense mediated decay - B2WTI3 - TSL:2,
JMJD6-207 ENST00000591460.1 667 No protein Retained intron - - - TSL:2,
JMJD6-206 ENST00000589982.1 467 No protein Retained intron - - - TSL:2,
Ubigene Red Cotton Transcript
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Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene JMJD6
This KO Strategy loading
Red Cotton™ Notes Gene JMJD6 had been KO in hek293t cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
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