Official symbol | ATG4B |
Gene id | 23192 |
Organism | Homo sapiens |
Official full symbol | autophagy related 4B cysteine peptidase |
Gene type | protein-coding |
Also known as | APG4B, AUTL1 |
Summary | Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Genomic regions | Chromosome 2 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
ATG4B-206 | ENST00000405546.7 | 3294 | 380aa | Protein coding | CCDS46565 | Q9Y4P1-6 | - | TSL:2, GENCODE basic, |
ATG4B-205 | ENST00000404914.8 | 2797 | 393aa | Protein coding | CCDS46564 | Q9Y4P1-1 | NM_013325.5 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
ATG4B-204 | ENST00000402096.5 | 1685 | 331aa | Protein coding | - | Q9Y4P1-4 | - | TSL:2, GENCODE basic, |
ATG4B-202 | ENST00000400771.7 | 663 | 219aa | Protein coding | - | C9JIK8 | - | CDS 3' incomplete, TSL:5, |
ATG4B-208 | ENST00000419606.5 | 553 | 66aa | Protein coding | - | C9J1C1 | - | CDS 3' incomplete, TSL:4, |
ATG4B-226 | ENST00000625810.2 | 370 | 88aa | Protein coding | - | F2Z2K8 | - | TSL:4, GENCODE basic, |
ATG4B-201 | ENST00000344376.9 | 1566 | 76aa | Nonsense mediated decay | - | H0Y2Y0 | - | CDS 5' incomplete, TSL:5, |
ATG4B-203 | ENST00000400772.6 | 625 | 88aa | Nonsense mediated decay | - | F2Z2K8 | - | TSL:4, |
ATG4B-207 | ENST00000415107.5 | 356 | 88aa | Nonsense mediated decay | - | F2Z2K8 | - | TSL:5, |
ATG4B-212 | ENST00000430617.6 | 623 | No protein | Processed transcript | - | - | - | TSL:3, |
ATG4B-222 | ENST00000491867.5 | 435 | No protein | Processed transcript | - | - | - | TSL:5, |
ATG4B-220 | ENST00000482507.5 | 2414 | No protein | Retained intron | - | - | - | TSL:1, |
ATG4B-225 | ENST00000494465.5 | 2365 | No protein | Retained intron | - | - | - | TSL:5, |
ATG4B-217 | ENST00000475693.1 | 2237 | No protein | Retained intron | - | - | - | TSL:2, |
ATG4B-221 | ENST00000483778.5 | 1103 | No protein | Retained intron | - | - | - | TSL:3, |
ATG4B-223 | ENST00000493618.5 | 899 | No protein | Retained intron | - | - | - | TSL:5, |
ATG4B-213 | ENST00000460211.5 | 871 | No protein | Retained intron | - | - | - | TSL:2, |
ATG4B-224 | ENST00000494132.1 | 828 | No protein | Retained intron | - | - | - | TSL:2, |
ATG4B-209 | ENST00000425239.5 | 807 | No protein | Retained intron | - | - | - | TSL:2, |
ATG4B-216 | ENST00000475195.5 | 762 | No protein | Retained intron | - | - | - | TSL:2, |
ATG4B-215 | ENST00000468018.5 | 721 | No protein | Retained intron | - | - | - | TSL:5, |
ATG4B-214 | ENST00000465399.5 | 581 | No protein | Retained intron | - | - | - | TSL:2, |
ATG4B-210 | ENST00000428861.1 | 580 | No protein | Retained intron | - | - | - | TSL:2, |
ATG4B-218 | ENST00000479554.5 | 556 | No protein | Retained intron | - | - | - | TSL:4, |
ATG4B-211 | ENST00000429899.1 | 524 | No protein | Retained intron | - | - | - | TSL:4, |
ATG4B-219 | ENST00000479941.1 | 374 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | ATG4B |
This KO Strategy | loading |
Red Cotton™ Notes | Gene ATG4B had been KO in hela cell line. |
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