CRISPR-U™ Gene Knockout Cell Line Strategy

ITGA11 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human ITGA11 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol ITGA11
Gene id 22801
Organism Homo sapiens
Official full symbol integrin subunit alpha 11
Gene type protein-coding
Also known as HsT18964
Summary This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
Genomic regions Chromosome 15
Strategy Summary
This gene has 2 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
ITGA11-201 ENST00000315757.9 10191 1188aa Protein coding CCDS45291 Q9UKX5-1 NM_001004439.2 TSL:1, GENCODE basic, APPRIS P2, MANE Select v0.92,
ITGA11-202 ENST00000423218.6 10192 1189aa Protein coding - Q9UKX5-2 - TSL:2, GENCODE basic, APPRIS ALT2,
ITGA11-203 ENST00000562826.5 670 No protein Processed transcript - - - TSL:3,
ITGA11-205 ENST00000566429.1 567 No protein Processed transcript - - - TSL:4,
ITGA11-207 ENST00000569346.5 783 No protein Retained intron - - - TSL:4,
ITGA11-206 ENST00000568677.1 651 No protein Retained intron - - - TSL:3,
ITGA11-204 ENST00000565868.5 401 No protein Retained intron - - - TSL:3,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene ITGA11
This KO Strategy loading
Red Cotton™ Notes Gene ITGA11 had been KO in hela cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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