Official symbol | ACSL3 |
Gene id | 2181 |
Organism | Homo sapiens |
Official full symbol | acyl-CoA synthetase long chain family member 3 |
Gene type | protein-coding |
Also known as | ACS3, FACL3, LACS 3, LACS3, PRO2194 |
Summary | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. |
Genomic regions | Chromosome 2 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
ACSL3-201 | ENST00000357430.8 | 5577 | 720aa | Protein coding | CCDS2455 | A0A024R487 O95573 | NM_004457.5 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
ACSL3-212 | ENST00000679514.1 | 5574 | 720aa | Protein coding | CCDS2455 | A0A024R487 | - | GENCODE basic, APPRIS P1, |
ACSL3-229 | ENST00000680921.1 | 5544 | 720aa | Protein coding | CCDS2455 | A0A024R487 | - | GENCODE basic, APPRIS P1, |
ACSL3-222 | ENST00000680395.1 | 5539 | 720aa | Protein coding | CCDS2455 | A0A024R487 | - | GENCODE basic, APPRIS P1, |
ACSL3-234 | ENST00000681383.1 | 5537 | 720aa | Protein coding | CCDS2455 | A0A024R487 | - | GENCODE basic, APPRIS P1, |
ACSL3-235 | ENST00000681697.1 | 5524 | 720aa | Protein coding | CCDS2455 | A0A024R487 | - | GENCODE basic, APPRIS P1, |
ACSL3-219 | ENST00000680147.1 | 5500 | 720aa | Protein coding | CCDS2455 | A0A024R487 | - | GENCODE basic, APPRIS P1, |
ACSL3-216 | ENST00000679558.1 | 5464 | 720aa | Protein coding | CCDS2455 | A0A024R487 | - | GENCODE basic, APPRIS P1, |
ACSL3-220 | ENST00000680251.1 | 5433 | 720aa | Protein coding | CCDS2455 | A0A024R487 | - | GENCODE basic, APPRIS P1, |
ACSL3-227 | ENST00000680684.1 | 5341 | 720aa | Protein coding | CCDS2455 | A0A024R487 | - | GENCODE basic, APPRIS P1, |
ACSL3-202 | ENST00000392066.7 | 3147 | 720aa | Protein coding | CCDS2455 | A0A024R487 O95573 | - | TSL:5, GENCODE basic, APPRIS P1, |
ACSL3-214 | ENST00000679545.1 | 5468 | 712aa | Protein coding | - | - | - | GENCODE basic, |
ACSL3-213 | ENST00000679541.1 | 5417 | 695aa | Protein coding | - | - | - | GENCODE basic, |
ACSL3-230 | ENST00000681009.1 | 5022 | 568aa | Protein coding | - | - | - | GENCODE basic, |
ACSL3-204 | ENST00000413316.1 | 650 | 88aa | Protein coding | - | C9JC11 | - | CDS 3' incomplete, TSL:4, |
ACSL3-210 | ENST00000540115.1 | 624 | 141aa | Protein coding | - | F5GWH2 | - | CDS 3' incomplete, TSL:3, |
ACSL3-236 | ENST00000681906.1 | 6794 | 518aa | Nonsense mediated decay | - | - | - | - |
ACSL3-223 | ENST00000680420.1 | 5680 | 659aa | Nonsense mediated decay | - | - | - | - |
ACSL3-225 | ENST00000680475.1 | 5652 | 518aa | Nonsense mediated decay | - | - | - | - |
ACSL3-226 | ENST00000680525.1 | 5545 | 518aa | Nonsense mediated decay | - | - | - | - |
ACSL3-228 | ENST00000680736.1 | 5479 | 283aa | Nonsense mediated decay | - | - | - | - |
ACSL3-232 | ENST00000681292.1 | 5341 | 283aa | Nonsense mediated decay | - | - | - | - |
ACSL3-203 | ENST00000407441.5 | 5244 | 434aa | Nonsense mediated decay | - | H7BYZ7 | - | TSL:3, |
ACSL3-224 | ENST00000680424.1 | 5311 | No protein | Processed transcript | - | - | - | - |
ACSL3-215 | ENST00000679546.1 | 2131 | No protein | Processed transcript | - | - | - | - |
ACSL3-205 | ENST00000421680.2 | 639 | No protein | Processed transcript | - | - | - | TSL:3, |
ACSL3-217 | ENST00000679932.1 | 8441 | No protein | Retained intron | - | - | - | - |
ACSL3-218 | ENST00000680100.1 | 6769 | No protein | Retained intron | - | - | - | - |
ACSL3-233 | ENST00000681326.1 | 6741 | No protein | Retained intron | - | - | - | - |
ACSL3-231 | ENST00000681017.1 | 4538 | No protein | Retained intron | - | - | - | - |
ACSL3-221 | ENST00000680382.1 | 1900 | No protein | Retained intron | - | - | - | - |
ACSL3-209 | ENST00000535678.2 | 1762 | No protein | Retained intron | - | - | - | TSL:3, |
ACSL3-207 | ENST00000474422.1 | 760 | No protein | Retained intron | - | - | - | TSL:3, |
ACSL3-208 | ENST00000495541.1 | 749 | No protein | Retained intron | - | - | - | TSL:2, |
ACSL3-206 | ENST00000463813.1 | 509 | No protein | Retained intron | - | - | - | TSL:3, |
ACSL3-211 | ENST00000542810.1 | 428 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | ACSL3 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene ACSL3 had been KO in hela cell line. |
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