Official symbol | EGF |
Gene id | 1950 |
Organism | Homo sapiens |
Official full symbol | epidermal growth factor |
Gene type | protein-coding |
Also known as | HOMG4, URG |
Summary | This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. |
Genomic regions | Chromosome 4 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
EGF-201 | ENST00000265171.10 | 6388 | 1207aa | Protein coding | CCDS3689 | P01133-1 | NM_001963.6 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
EGF-206 | ENST00000509793.5 | 4489 | 1165aa | Protein coding | CCDS54795 | P01133-2 | - | TSL:2, GENCODE basic, |
EGF-204 | ENST00000503392.1 | 3642 | 1166aa | Protein coding | CCDS54794 | P01133-3 | - | TSL:1, GENCODE basic, |
EGF-213 | ENST00000652245.1 | 5923 | 1010aa | Protein coding | - | A0A494C018 | - | GENCODE basic, |
EGF-203 | ENST00000502723.1 | 683 | No protein | Processed transcript | - | - | - | TSL:3, |
EGF-211 | ENST00000541061.1 | 432 | No protein | Processed transcript | - | - | - | TSL:3, |
EGF-207 | ENST00000509996.1 | 1464 | No protein | Retained intron | - | - | - | TSL:1, |
EGF-212 | ENST00000544918.1 | 773 | No protein | Retained intron | - | - | - | TSL:3, |
EGF-205 | ENST00000504633.1 | 584 | No protein | Retained intron | - | - | - | TSL:3, |
EGF-202 | ENST00000502579.1 | 580 | No protein | Retained intron | - | - | - | TSL:3, |
EGF-208 | ENST00000511228.5 | 567 | No protein | Retained intron | - | - | - | TSL:4, |
EGF-209 | ENST00000537316.5 | 491 | No protein | Retained intron | - | - | - | TSL:3, |
EGF-210 | ENST00000540840.1 | 324 | No protein | Retained intron | - | - | - | TSL:3, |
Target Gene | EGF |
This KO Strategy | loading |
Red Cotton™ Notes | Gene EGF had been KO in hela cell line. |
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