Official symbol | DDIT3 |
Gene id | 1649 |
Organism | Homo sapiens |
Official full symbol | DNA damage inducible transcript 3 |
Gene type | protein-coding |
Also known as | AltDDIT3, C/EBPzeta, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 |
Summary | This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. |
Genomic regions | Chromosome 12 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
DDIT3-204 | ENST00000551116.5 | 1067 | 192aa | Protein coding | CCDS55838 | P35638-2 | - | TSL:1, GENCODE basic, |
DDIT3-205 | ENST00000552740.5 | 951 | 192aa | Protein coding | CCDS55838 | P35638-2 | - | TSL:1, GENCODE basic, |
DDIT3-206 | ENST00000623876.2 | 940 | 169aa | Protein coding | CCDS8943 | P35638-1 | - | TSL:NA, GENCODE basic, APPRIS P1, |
DDIT3-201 | ENST00000346473.7 | 906 | 169aa | Protein coding | CCDS8943 | P35638-1 | - | TSL:1, GENCODE basic, APPRIS P1, |
DDIT3-202 | ENST00000547303.5 | 872 | 169aa | Protein coding | CCDS8943 | P35638-1 | - | TSL:2, GENCODE basic, APPRIS P1, |
DDIT3-203 | ENST00000547526.1 | 644 | 145aa | Protein coding | - | F8W133 | - | CDS 3' incomplete, TSL:3, |
Target Gene | DDIT3 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene DDIT3 had been KO in hela cell line. |
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