CRISPR-U™ Gene Knockout Cell Line Strategy

CREB3L4 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human CREB3L4 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol CREB3L4
Gene id 148327
Organism Homo sapiens
Official full symbol cAMP responsive element binding protein 3 like 4
Gene type protein-coding
Also known as AIBZIP, ATCE1, CREB3, CREB4, JAL, hJAL
Summary This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene.
Genomic regions Chromosome 1
Strategy Summary
This gene has 7 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
CREB3L4-201 ENST00000271889.8 1750 395aa Protein coding CCDS1056 Q8TEY5-1 - TSL:1, GENCODE basic, APPRIS P4,
CREB3L4-205 ENST00000368607.8 1749 395aa Protein coding CCDS1056 Q8TEY5-1 NM_001255978.2 TSL:1, GENCODE basic, APPRIS P4, MANE Select v0.92,
CREB3L4-204 ENST00000368603.5 1557 395aa Protein coding CCDS1056 Q8TEY5-1 - TSL:1, GENCODE basic, APPRIS P4,
CREB3L4-202 ENST00000368600.7 1496 375aa Protein coding CCDS58029 Q8TEY5-2 - TSL:1, GENCODE basic, APPRIS ALT2,
CREB3L4-207 ENST00000449724.5 982 228aa Protein coding - Q5T4L1 - CDS 3' incomplete, TSL:5,
CREB3L4-203 ENST00000368601.5 950 217aa Protein coding - Q5T4K9 - TSL:2, GENCODE basic,
CREB3L4-206 ENST00000431292.1 602 182aa Protein coding - Q5T4L2 - CDS 3' incomplete, TSL:5,
CREB3L4-209 ENST00000468845.1 906 No protein Processed transcript - - - TSL:3,
CREB3L4-210 ENST00000473340.1 880 No protein Processed transcript - - - TSL:2,
CREB3L4-208 ENST00000461688.5 870 No protein Processed transcript - - - TSL:5,
CREB3L4-213 ENST00000492729.1 835 No protein Processed transcript - - - TSL:5,
CREB3L4-212 ENST00000479010.1 612 No protein Processed transcript - - - TSL:2,
CREB3L4-211 ENST00000477617.5 568 No protein Processed transcript - - - TSL:2,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene CREB3L4
This KO Strategy loading
Red Cotton™ Notes Gene CREB3L4 had been KO in hela cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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